My MGUS diagnosis
Hi, I’m 48 years old. My primary care doctor noticed that my total proteins were elevated 8.3 g/dl back in January of this year on my routine bloodwork, nothing else was out of range. He did a serum protein electrophoresis test in April along with routine blood. Again everything was in normal range except on the spep my beta 2 globulins was 1.4 g/dl and my gamma globulins were 2.1 g/dl and my total protein was 8.4g/dl .The results also stated “No M-Spike observed”, “ The SPE pattern reflects a polyclonal increase in gamma globulin.Hypergammaglobulinemia is found in a wide variety of infectious, non-infectious, and autoimmune disease states.Evidence of monoclonal protein is not apparent”. He said we will run another protein electrophoresis in June which he did and my beta globulins 1.4 g/dl was and my gamma globulins were 2.0 g/dl and my total protein was 8.1 g/dl.Again,the results also stated “No M-Spike observed”, “ The SPE pattern reflects a polyclonal increase in gamma globulin.Hypergammaglobulinemia is found in a wide variety of infectious, non-infectious, and autoimmune disease states.Evidence of monoclonal protein is not apparent”. He then referred me to an oncologist/ hematologist. She ran cbc with differential/platelet,Comp.Metabolic Panel, immunofixation serum, Free K+L Lt Chains,Qn,S.The only tests that was abnormal from the test set order are the one’s below The result were
Immunofixation Results - Abnormal
Note: “Polyclonal increase detected in one or more immunoglobulins
IgG - 1944 mg/dl
IgA - 450 mg/dl
IgM - 373 mg/dl
Kappa 25.7
Lambda 15.0
kappa/lambda ratio - 1.66
I was diagnosed with mgus and lab work will be done in another 6 months. This is all I can think about now. Very stressed and overwhelmed with emotional. I’ve tried to the avoid the obvious intrusive thoughts that arise but it has been tough. It a little depressing to just have this thing that can turn deadly at any moment and there is literally nothing that can be done at this point to stop it this early.tThis wait and see is not a strategy, and I was not comforted at all by this mgus progression statistics of 1% at all. I apologize in advance is my response is out of character about my lab results and mgus diagnosis but I really so sad having this mgus.Any thoughts on my lab results are much appreciated