What's a card that you will usually take, even before it is practical / synergizes with what you have?
Maybe it's not even all that good (especially taking it too early), but your monkey brain urges you to not pass it up.
For example:
a non-upgraded Barricade when you have 3 energy and an offensive setup
a Limit Break when you have no strength cards
For my part, it's Fire Breathing. I see that earlier enough, and I just want to build my whole run around it, win chances be damned.